Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands

Autor:	Ken-ichi Wakabayashi, Hiroyuki Miyachi, Jun Ichi Kasuga, Makoto Makishima, Kazuo Nagasawa, Shinnosuke Hosoda, Masahiko Kainuma, Aya Tanatani, Yuichi Hashimoto
Rok vydání:	2006
Předmět:	Agonist Transcription Genetic medicine.drug_class Stereochemistry medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Peroxisome proliferator-activated receptor Receptors Cytoplasmic and Nuclear Diphenylmethane Ligands Biochemistry Steroid chemistry.chemical_compound Drug Discovery medicine Humans PPAR alpha Benzhydryl Compounds Receptor Molecular Biology chemistry.chemical_classification Molecular Structure Chemistry Ligand Organic Chemistry DNA-Binding Proteins Nuclear receptor Molecular Medicine Farnesoid X receptor Transcription Factors
Zdroj:	Bioorganicmedicinal chemistry letters. 16(12)
ISSN:	0960-894X
Popis:	Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837e0c6d29d6d39eeb7ed0e69790f422 https://pubmed.ncbi.nlm.nih.gov/16617018 Zobrazit plný text záznamu Full Text from ScienceDirect