Ovariectomy Causes Overexpression of Renal Na+,K+-ATPase and Sodium-Sensitive Hypertension in Adult Wistar Rats
| Autor: | Elisabet M. Oddo, Jorge E. Toledo, Fernando R. Ibarra, Pablo Javier Azurmendi, Elvira Arrizurieta, Federico Ochoa, Luis A. Di Ciano, Elsa Zotta |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Renal Plasma Flow Physiology Ovariectomy Sodium High sodium Natriuresis Hemodynamics chemistry.chemical_element Blood Pressure Kidney α1 subunit Internal medicine Internal Medicine medicine Animals Rats Wistar Na+/K+-ATPase Chemistry Ovary Sodium Dietary General Medicine Electrolyte excretion Rats Endocrinology Renal blood flow Hypertension Loop of Henle Female Normal sodium Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Clinical and Experimental Hypertension. 35:475-483 |
| ISSN: | 1525-6006 1064-1963 |
| Popis: | We investigated the effect of ovariectomy(oVx) on renal and systemic hemodynamic, electrolyte excretion and total and dephosphorylated Na(+),K(+)-ATPase α1 subunit (t-d-NKA) in normotensive Wistar rats under a normal sodium (NS, 0.24%) or high sodium (HS, 1%) intake versus intact female (IF). On NS intake, t-d-NKA was higher in oVx rats and overexpressed in the thick ascending limbs (P .01 vs. IF) and renal plasma flow was increased. On HS intake, oVx rats maintained a greater dephosphorylated NKA, excreted less sodium, and developed arterial hypertension (134 ± 4 vs. IF 112 ± 5 mm Hg, P .05). Sodium load caused salt-sensitive hypertension in oVx Wistar rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |