Genomic landscape of Epstein–Barr virus in familial nasopharyngeal carcinoma
| Autor: | Wen-Li Zhang, Jiang-Bo Zhang, Tong-Min Wang, Yan-Xia Wu, Yong-Qiao He, Wen-Qiong Xue, Ying Liao, Chang-Mi Deng, Dan-Hua Li, Zi-Yi Wu, Da-Wei Yang, Xiao-Hui Zheng, Xi-Zhao Li, Ting Zhou, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Wei-Hua Jia |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of General Virology. 103 |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | To better understand the genomic characteristics of Epstein–Barr virus (EBV) in familial nasopharyngeal carcinoma (NPC), we sequenced the EBV genomes by whole-genome capture in 38 unrelated patients with NPC family history in first-degree relatives and 47 healthy controls, including 13 with family history and 34 without. Compared with type 1 reference genome, mutation hotspots were observed in the latent gene regions of EBV in familial NPC cases. Population structure analysis showed that one cluster has a higher frequency in familial cases than in controls (OR=5.33, 95 % CI 2.50–11.33, P=1.42×10−5), and similar population structure composition was observed among familial and sporadic NPC cases in high-endemic areas. By genome-wide association analysis, four variants were found to be significantly associated with familial NPC. Consistent results were observed in the meta-analysis integrating two published case-control EBV sequencing studies in NPC high-endemic areas. High-risk haplotypes of EBV composed of 34 variants were associated with familial NPC risk (OR=13.85, 95 % CI 4.13–46.44, P=2.06×10−5), and higher frequency was observed in healthy blood-relative controls with NPC family history (9/13, 69.23 %) than those without family history (16/34, 47.06%). This study suggested the potential contribution of EBV high-risk subtypes to familial aggregation of NPC. |
| Databáze: | OpenAIRE |
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