Pharmacokinetics and brain penetration study of chlorogenic acid in rats
| Autor: | Nishant Patnaik, Ranjana Patnaik, Sumedha Mukherjee, Sairam Krishnamurthy, Gaurav Kumar, Pankaj Paliwal |
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| Rok vydání: | 2018 |
| Předmět: |
Male
endocrine system Health Toxicology and Mutagenesis Pharmacology Toxicology 030226 pharmacology & pharmacy Biochemistry Plasma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chlorogenic acid Pharmacokinetics Animals Administration Intranasal Chromatography High Pressure Liquid Cerebrospinal Fluid Brain General Medicine Penetration (firestop) Rats Neuroprotective Agents chemistry Blood-Brain Barrier 030220 oncology & carcinogenesis Nasal administration Chlorogenic Acid |
| Zdroj: | Xenobiotica. 49:339-345 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.1080/00498254.2018.1445882 |
| Popis: | 1. The present study is designed to investigate the brain distribution and plasma pharmacokinetics profiles of chlorogenic acid (CGA) after intranasal administration in Charles-Foster rats to evaluate whether the CGA molecules are transported directly via the nose-to-brain path. 2. The CGA is administered intravenously (IV) and intranasally (IN) at the dose of 10 mg/kg. Further, its concentration in the plasma, cerebrospinal fluid (CSF) and the whole brain is analyzed by HPLC-UV method. 3. The study observes that CGA is rapidly absorbed in plasma with t |
| Databáze: | OpenAIRE |
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