A randomized controlled trial of intranasal ketamine in migraine with prolonged aura
| Autor: | Holger Kaube, Peter J. Goadsby, Nicola J. Giffin, Shazia K. Afridi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Aura Midazolam Migraine with Aura Severity of Illness Index law.invention Young Adult Double-Blind Method Randomized controlled trial law Outpatients Severity of illness Humans Medicine Intranasal Ketamine Ketamine Longitudinal Studies Administration Intranasal Analgesics Inpatients business.industry Middle Aged medicine.disease Treatment Outcome Migraine Anesthesia Cortical spreading depression Female Neurology (clinical) business medicine.drug |
| Zdroj: | Neurology. 80:642-647 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/wnl.0b013e3182824e66 |
| Popis: | Objective: The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura. Methods: We performed a double-blinded, randomized parallel-group controlled study investigating the effect of 25 mg intranasal ketamine on migraine with prolonged aura in 30 migraineurs using 2 mg intranasal midazolam as an active control. Each subject recorded data from 3 episodes of migraine. Results: Eighteen subjects completed the study. Ketamine reduced the severity ( p = 0.032) but not duration of aura in this group, whereas midazolam had no effect. Conclusions: These data provide translational evidence for the potential importance of glutamatergic mechanisms in migraine aura and offer a pharmacologic parallel between animal experimental work on cortical spreading depression and the clinical problem. Classification of evidence: This study provides Class III evidence that intranasal ketamine is effective in reducing aura severity in patients with migraine with prolonged aura. |
| Databáze: | OpenAIRE |
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