Surface morphology control of polylactide microspheres enclosing irinotecan hydrochloride

Autor:	Takashi Aiko, Hidekazu Yoshizawa, Yoshiro Kitamura, Satoru Nishino, Shoji Natsugoe, Koichiro Shiomori
Rok vydání:	2005
Předmět:	Antitumor activity Materials science Morphology (linguistics) Surface Properties Scanning electron microscope Polyesters Pharmaceutical Science Nanotechnology Irinotecan Microspheres Microsphere Polyester Chemical engineering Emulsion Irinotecan Hydrochloride Camptothecin Microparticle
Zdroj:	International Journal of Pharmaceutics. 296:112-116
ISSN:	0378-5173
DOI:	10.1016/j.ijpharm.2005.02.010
Popis:	In order to reduce the initial burst from polylactide (PLA) microspheres enclosing an antitumor agent, we prepared the microspheres with a smooth surface by varying solvent evaporation conditions such as operating temperature and pressure. PLA microspheres enclosing irinotecan hydrochloride (CPT) were prepared using the O/O emulsion system for solvent evaporation. The mean diameter and enclosing efficiency were almost constant because they were independent of solvent evaporation conditions. Scanning electron microscopic (SEM) observation verified the smooth surface of the PLA microspheres produced by varying the preparation conditions. In vitro release experiments show that the initial burst of microspheres with a smooth surface was less than that of those with a rough surface.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837a2d8777f35b25c08d1c124d32e6c4 https://doi.org/10.1016/j.ijpharm.2005.02.010 Zobrazit plný text záznamu Full Text from ScienceDirect