Prenatal Exposure to Lipopolysaccharide Results in Myocardial Fibrosis in Rat Offspring

Autor: Meng Gao, Jianzhi Zhou, Yujie Tang, Xiaohui Li, Xin Chen, Shugang Qin
Rok vydání: 2015
Předmět:
Lipopolysaccharides
Male
Pyrrolidines
MMP2
Lipopolysaccharide
pyrrolidine dithiocarbamic acid
Rats
Sprague-Dawley
lcsh:Chemistry
chemistry.chemical_compound
Pregnancy
Transforming Growth Factor beta
Fibrosis
Myocardial infarction
lcsh:QH301-705.5
Spectroscopy
lipopolysaccharide
NF-kappa B
Gene Expression Regulation
Developmental
General Medicine
Computer Science Applications
Prenatal Exposure Delayed Effects
Matrix Metalloproteinase 2
Female
Cardiomyopathies
medicine.medical_specialty
Offspring
Article
Catalysis
Inorganic Chemistry
Thiocarbamates
pregnant
Internal medicine
medicine
Animals
Physical and Theoretical Chemistry
Molecular Biology
Tissue Inhibitor of Metalloproteinase-2
business.industry
Myocardium
Organic Chemistry
medicine.disease
Rats
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
Heart failure
myocardial fibrosis
Myocardial fibrosis
business
Zdroj: International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 10986-10996 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 5
Pages 10986-10996
ISSN: 1422-0067
DOI: 10.3390/ijms160510986
Popis: The epigenetic plasticity hypothesis indicates that exposure during pregnancy may cause adult-onset disorders, including hypertension, myocardial infarction and heart failure. Moreover, myocardial fibrosis coincides with hypertension, myocardial infarction and heart failure. This study was designed to investigate the effects of prenatal exposure to lipopolysaccharide (LPS) on myocardial fibrosis. The result showed that at six and 16 weeks of age, the LPS-treated offspring exhibited increased collagen synthesis, an elevated cardiac index (CI), higher mRNA levels of TIMP-2 and TGFβ and a reduced mRNA level of MMP2. The protein levels corresponded to the mRNA levels. The offspring that were prenatally treated with pyrrolidine dithiocarbamic acid (PDTC), an inhibitor of NF-κB, displayed improvements in the CI and in collagen synthesis. Moreover, PDTC ameliorated the expression of cytokines and proteins associated with myocardial fibrosis. The results showed that maternal inflammation can induce myocardial fibrosis in offspring during aging accompanied by an imbalance of TIMP-2/MMP2 and TGFβ expression.
Databáze: OpenAIRE
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