Diffusion-weighted MRI for uveal melanoma liver metastasis detection
| Autor: | Pascale Mariani, Manuel Rodrigues, Vincent Servois, Fereshteh Farkhondeh, Sophie Piperno-Neumann, Nathalie Cassoux, François-Clément Bidard, Slavomir Petras, Mathilde Wagner |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Uveal Neoplasms medicine.medical_specialty Contrast Media Gadolinium McNemar's test Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Melanoma Neuroradiology Aged Retrospective Studies medicine.diagnostic_test business.industry Ultrasound Liver Neoplasms Interventional radiology Magnetic resonance imaging General Medicine Middle Aged medicine.disease Diffusion Magnetic Resonance Imaging Female Radiology business Diffusion MRI |
| Zdroj: | European radiology. 25(8) |
| ISSN: | 1432-1084 |
| Popis: | We aimed to assess the sensitivity of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of pathologically confirmed uveal melanoma liver metastases (UMLM). Twenty patients who underwent complete surgical resection of their UMLM (N = 83) were included. Pre-surgery liver MR imaging included T2-weighted, T1-weighted, DW and dynamic-gadolinium-enhanced MR sequences. Two radiologists independently reviewed three sets of images (DW / morphologic-dynamic / combined) for each patient using intraoperative and pathological findings as a standard of reference. The sensitivities of the morphologic-dynamic and DW images for UMLM detection were 63 % and 59 %, respectively, for reader #1 (R1) and 64 % and 53 %, for reader #2 (R2). Sensitivity of the combined set was higher than sensitivity in the two other sets (R1:69 %, R2:67 %), but was only significantly different than the sensitivity of the DW images (McNemar test). For the three sets and the two readers, the sensitivity for UMLM smaller than 5 mm (37–46 %) was significantly lower than that for UMLM larger than 5 mm (67–90 %). The sensitivity for UMLM located in the subcapsular area (41–54 %) was significantly lower than that for intraparenchymal UMLM (68–86 %) (Chi-square test). Our study shows that the addition of DW imaging to morphologic-dynamic images does not significantly increase MR sensitivities for UMLM detection. • The MR imaging sensitivity for uveal melanoma liver metastases (UMLM) was 69 %. • Addition of DW imaging to morphologic-dynamic images does not increase sensitivity significantly. • Sensitivity for subcapsular UMLM was significantly lower than sensitivity for intraparenchymal UMLM. • The T2 shortening effect does not appear to influence lesion detection in DWI. |
| Databáze: | OpenAIRE |
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