Detection of bone marrow involvement with FDG PET/CT in patients with newly diagnosed lymphoma
| Autor: | Sahre Özpolat, Ebru Yilmaz, Seher Ünal, Meliha Nalcaci, Hasan Sami Goksoy, H. Tahsin Özpolat, Oner Dogan |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Lymphoma PET/CT Single Center Bone marrow biopsy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine White blood cell Biopsy medicine Focal involvement Fluorodeoxyglucose PET-CT medicine.diagnostic_test business.industry Hematology medicine.disease Diffuse medicine.anatomical_structure Bone marrow involvement Positron emission tomography 030220 oncology & carcinogenesis Original Article Radiology Bone marrow business medicine.drug |
| Zdroj: | Blood research |
| ISSN: | 2288-0011 2287-979X |
| Popis: | Background Bone marrow involvement (BMI) affects the lymphoma stage, survival, and treatment. Bone marrow biopsy (BMB) and fluorodeoxyglucose (FDG) positron emission tomography- computed tomography (PET/CT) are useful techniques to detect BMI. Both have advantages and disadvantages. We aimed to identify factors that could be used to predict BMI with positive and negative results on PET/CT compare them with BMB in newly diagnosed patients with lymphoma. Methods We included 22 non-Hodgkin and 16 Hodgkin lymphoma patients in this single center study. All patients had PET/CT examination and BMB before treatment. BMI in BMB was reported as negative or positive. Bone marrow was classified into 3 types by FDG uptake on PT/CT; diffuse involvement, focal involvement, and normal bone marrow. Results PET/CT and BMB results were concordant (7 positive, 15 negative) in 22 patients (57%). We evaluated concordant and discordant patient characteristics and risk-stratified patients for BMI. Our findings suggest that patients with diffuse FDG uptake on PET/CT, especially patients with advanced age and low platelet and white blood cell counts, are likely to have BMI and could potentially forego BMB. Patients with negative PET/CT findings and no significant laboratory abnormalities are very unlikely to have BMI. Conclusion Our results suggest that BMI should not be decided solely based PET/CT or BMB findings. It is reasonable to use both diagnostic assays along with clinical and laboratory findings. PET/CT result, clinical and laboratory findings could be useful for predicting BMI in patient for whom BMB is contraindicated. |
| Databáze: | OpenAIRE |
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