Relationship between illness uncertainty, anxiety, fear of progression and quality of life in men with favourable-risk prostate cancer undergoing active surveillance
| Autor: | George Baum, Deborah A. Kuban, David M. Latini, Xuemei Wang, John W. Davis, Patricia A. Parker, Christopher J. Logothetis, Andrew K. Lee, John F. Ward, Jeri Kim, Steven J. Frank |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Gerontology medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Psychological intervention Article 03 medical and health sciences Prostate cancer 0302 clinical medicine Quality of life Risk Factors Humans Medicine Prospective Studies Watchful Waiting Psychiatry Prospective cohort study Aged Aged 80 and over business.industry Uncertainty Prostatic Neoplasms Fear Middle Aged medicine.disease Anxiety Disorders 030220 oncology & carcinogenesis Disease Progression Quality of Life Anxiety medicine.symptom Sexual function business Watchful waiting Cohort study |
| Zdroj: | BJU International. 117:469-477 |
| ISSN: | 1464-4096 |
| DOI: | 10.1111/bju.13099 |
| Popis: | To evaluate prospectively the associations between illness uncertainty, anxiety, fear of progression and general and disease-specific quality of life (QoL) in men with favourable-risk prostate cancer undergoing active surveillance (AS).After meeting stringent enrollment criteria for an AS cohort study at a single tertiary care cancer centre, 180 men with favourable-risk prostate cancer completed questionnaires at the time of enrollment and every 6 months for up to 30 months. Questionnaires assessed illness uncertainty, anxiety, prostate-specific QoL (using the Expanded Prostate Cancer Index Composite [EPIC] scale) and general QoL (using the 12-time short-form health survey [SF-12]) and fear of progression. We used linear mixed-model analyses and multilevel mediation analyses.Sexual scores on the EPIC scale significantly declined over time (P0.05). Illness uncertainty was a significant predictor of all EPIC summary scores, SF-12 physical component summary (PCS) scores, mental component summary (MCS) scores and fear of progression scores (all P0.05), after controlling for demographic and clinicopathological factors. Anxiety predicted all EPIC summary, MCS and fear of progression scores (all P0.05) but not PCS scores (P = 0.08). Scores on PCS, MCS, EPIC summary scales (except sexual scale), and fear of progression did not change significantly over the study period (all P0.10).Over the 2.5-year follow-up, QoL remained stable; only sexual function scores significantly declined. Illness uncertainty and anxiety were significant predictors of general and prostate-specific QoL and fear of progression. Interventions to reduce uncertainty and anxiety may enhance QoL for men with prostate cancer on AS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text