Reshaping the tumor microenvironment for increasing the distribution of glucose oxidase in tumor and inhibiting metastasis
| Autor: | Shengnan Li, Shizhen Geng, Rui Lou, Ruhe Yang, Qianwen Yin, Jie Zhou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell
Biomedical Engineering Metastasis Glucose Oxidase In vivo Tumor Microenvironment polycyclic compounds medicine Humans Distribution (pharmacology) General Materials Science Glucose oxidase Neoplasm Metastasis chemistry.chemical_classification Tumor microenvironment Reactive oxygen species biology Chemistry General Chemistry General Medicine medicine.disease Cell biology medicine.anatomical_structure biology.protein Nucleus hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Materials Chemistry B. 9:1424-1431 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d0tb02468f |
| Popis: | The poor penetration of solid tumors hinders the development of hunger therapy represented by glucose oxidase (GOx). To address this limitation, we have constructed a GOx/Dex@ZIF-TA nanosystem consisting of tannic acid (TA), carrier ZIF-8, encapsulated GOx and dexamethasone (Dex). In this nanosystem, the loaded Dex can not only expand the pores of the nucleus to promote GOx to enter the nucleus, addressing the shortcomings of short life of reactive oxygen species, but also inhibit the production of collagen to reshape the tumor microenvironment and inhibit lung metastasis. In vivo experiments proved that Dex could inhibit the production of collagen, which increased the accumulation and penetration of the tumor tissues and inhibited lung metastasis. In addition, cell experiments showed that Dex could also enlarge the nuclear pores of the nucleus and promote the entry of drugs into the nucleus. More importantly, Dex is a broad anti-inflammatory drug, and the results of this study should be easily transformed to achieve clinical benefits. Together, this work provided a way to address the limitations of hunger distribution in tumor tissues. |
| Databáze: | OpenAIRE |
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