The action of echis carinatus venom on the blood coagulation system

Autor: H.C. Hemker, P.P. Devilee, M.C.E. van Dam-Mieras
Přispěvatelé: Biochemie
Jazyk: angličtina
Rok vydání: 1984
Předmět:
Zdroj: Thrombosis Research, 35(1), 1-9. Elsevier Science
ISSN: 0049-3848
DOI: 10.1016/0049-3848(84)90307-4
Popis: It is shown that Echis carinatus venom activates both coagulation factor II and coagulation factor X. The activation of both proenzymes by the venom is Ca++-dependent; phospholipids are not necessary. The activation of factor II by the venom is a slow process and, in the absence of factor X, the clotting activity towards fibrinogen is generated only very slowly. Because Echis carinatus venom clots plasma readily, we postulate that under conditions where the prothrombinase complex can be formed from the factor X activated by the venom it is this complex, rather than the venom itself, that is responsible for the major part of the thrombin formation.
Databáze: OpenAIRE