α-Pyrone and Sterol Constituents of Penicillium aurantiacobrunneum, a Fungal Associate of the Lichen, Niebla homalea
| Autor: | Choon Yong Tan, Chad A. Rappleye, Gerardo D. Anaya-Eugenio, A. Douglas Kinghorn, Richard W. Spjut, Judith C. Gallucci, Fengrui Wang, L. Harinantenaina Rakotondraibe, Esperanza J. Carcache de Blanco, Kristie D. Goughenour |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Lichens
Stereochemistry Penicillium aurantiacobrunneum Pharmaceutical Science Crystallography X-Ray 01 natural sciences Article Analytical Chemistry chemistry.chemical_compound Niebla homalea Cell Line Tumor Drug Discovery Humans Lichen Pharmacology Molecular Structure 010405 organic chemistry Spectrum Analysis Organic Chemistry Fungi Penicillium Pyrone Sterol 0104 chemical sciences 010404 medicinal & biomolecular chemistry Sterols Complementary and alternative medicine chemistry Pyrones Molecular Medicine Drug Screening Assays Antitumor Paxisterol |
| Zdroj: | J Nat Prod |
| Popis: | Four new metabolites, 4-epi-citreoviridin (1), auransterol (3), and two analogues (2 and 4) of paxisterol (6), together with two known metabolites (15R*,20S*)-dihydroxyepisterol (5) and (6), were isolated from cultures of the fungal associate, Penicillium aurantiacobrunneum of the lichen, Niebla homalea, endemic to California and Baja California. The structures of all compounds were determined by comprehensive spectroscopic and spectrometric methods, including single-crystal X-ray diffraction for the determination of the absolute configuration of 3. Compound 1 showed selective cytotoxicity towards MCF-7 breast and A2780 ovarian cells with IC(50) values of 4.2 and 5.7 μM respectively. |
| Databáze: | OpenAIRE |
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