α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure
| Autor: | N Stojiljkovic, Marko Z. Mladenović, M Veljkovic, J Todorovic, S Ilic |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.drug_class Kidney Glomerulus alpha-Tocopherol Antibiotics Pharmacology medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Combined treatment Malondialdehyde medicine Animals Oxidative injury Tocopherol Rats Wistar skin and connective tissue diseases urogenital system business.industry food and beverages General Medicine Acute Kidney Injury Catalase Rats Oxidative Stress Kidney Tubules 030104 developmental biology lipids (amino acids peptides and proteins) Gentamicin sense organs Basal membrane Gentamicins business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 164:442-445 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4008-y |
| Popis: | We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic. |
| Databáze: | OpenAIRE |
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