Persistence on Anti-Tumour Necrosis Factor Therapy in Older Patients with Inflammatory Bowel Disease Compared with Younger Patients: Data from the Sicilian Network for Inflammatory Bowel Diseases (SN-IBD)

Autor:	Fabio Salvatore Macaluso, Gaetano Inserra, Marco Ventimiglia, Maria Cappello, Mario Cottone, Antonio Carroccio, Angela Alibrandi, Antonino Carlo Privitera, Walter Fries, Filippo Mocciaro, N. Belluardo, A. Magnano, Sara Renna, S. Siringo, S. Garufi, Serena Porcari, C. Ferracane, Ambrogio Orlando, Alessandro Vitello, C. Bertolami, Oriana Fidanza, Roberto Di Mitri, Anna Viola, G. Magrì
Přispěvatelé:	Porcari S, Viola A, Orlando A, Privitera AC, Ferracane C, Cappello M, Vitello A, Siringo S, Inserra G, Magnano A, Mocciaro F, Di Mitri R, Belluardo N, Fidanza O, Garufi S, Magrì G, Bertolami C, Carroccio A, Macaluso FS, Renna S, Ventimiglia M, Alibrandi A, Cottone M, Fries W
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Settore MED/09 - Medicina Interna Drug-Related Side Effects and Adverse Reactions Kaplan-Meier Estimate Anti-Tumour Necrosis Factor Disease Inflammatory bowel disease Cohort Studies 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Internal medicine medicine Humans Pharmacology (medical) Treatment Failure 030212 general & internal medicine Adverse effect Aged Retrospective Studies Aged 80 and over Tumor Necrosis Factor-alpha business.industry Inflammatory Bowel Disease Adalimumab Age Factors Antibodies Monoclonal Retrospective cohort study Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Infliximab Sicilian Network for Inflammatory Bowel Diseases (SN-IBD) Withholding Treatment Concomitant Female Geriatrics and Gerontology business 030217 neurology & neurosurgery Cohort study
Zdroj:	Drugs & Aging. 37:383-392
ISSN:	1179-1969 1170-229X
Popis:	BACKGROUND AND OBJECTIVE: Older people with inflammatory bowel disease (IBD) appear to have a lower response to anti-tumour necrosis factor (TNF) therapy, with more frequent complications than younger patients. The objective of this study was to assess persistence on therapy and the safety of anti-TNF therapy in older patients (aged ≥ 60 years). METHODS: We retrospectively reviewed the database of the Sicilian Network for Inflammatory Bowel Diseases (SN-IBD), extracting data regarding IBD patients aged ≥ 60 years and controls
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836e9cf59f5bc6b58e1d561e5ee90fac https://doi.org/10.1007/s40266-020-00744-3 Zobrazit plný text záznamu Full text from SpringerLink