Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study
| Autor: | Michael P. Brönnimann, Lea Hirzberger, Peter M. Keller, Monika Gsell-Albert |
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| Rok vydání: | 2023 |
| Předmět: |
microbial sensitivity tests
Organic Chemistry 610 Medicine & health General Medicine interventional contrast media Catalysis Computer Science Applications minimally invasive surgical procedures Inorganic Chemistry anti-bacterial agents antibacterial effect magnetic resonance imaging 570 Life sciences biology anti-infective agents Physical and Theoretical Chemistry Molecular Biology Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences Volume 24 Issue 4 Pages: 3470 Brönnimann, Michael P.; Hirzberger, Lea; Keller, Peter M.; Gsell-Albert, Monika (2023). Antibacterial Effects of X-ray and MRI Contrast Media: An In Vitro Pilot Study. International journal of molecular sciences, 24(4), p. 3470. MDPI 10.3390/ijms24043470 |
| DOI: | 10.48350/178578 |
| Popis: | Some radiological contrast agents have been shown to have effects on bacterial growth. In this study, the antibacterial effect and mechanism of action of iodinated X-ray contrast agents (Ultravist 370, Iopamiro 300, Telebrix Gastro 300 and Visipaque) and complexed lanthanide MRI contrast solutions (MultiHance and Dotarem) were tested against six different microorganisms. Bacteria with high and low concentrations were exposed to media containing different contrast media for various lengths of time and at pH 7.0 and 5.5. The antibacterial effect of the media was examined in further tests using agar disk diffusion analysis and the microdilution inhibition method. Bactericidal effects were found for microorganisms at low concentrations and low pH. Reductions were confirmed for Staphylococcus aureus and Escherichia coli. |
| Databáze: | OpenAIRE |
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