Motor weakness and cerebellar ataxia in Sjögren syndrome—identification of antineuronal antibody: a case report
| Autor: | Kuniaki Tsuchiya, Kiyoshi Owada, Kazuyuki Ishida, Toshiki Uchihara, Hidehiro Mizusawa, Sadakiyo Watabiki |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty Cerebellar Ataxia Blotting Western Neurological disorder Mice Purkinje Cells Cerebrospinal fluid Dorsal root ganglion medicine Animals Humans Autoantibodies Motor Neurons Muscle Weakness Cerebellar ataxia business.industry Autoantibody Middle Aged medicine.disease Spinal cord Immunohistochemistry Magnetic Resonance Imaging Rats Sjogren's Syndrome medicine.anatomical_structure Neurology Cerebellar cortex Immunology Cattle Female Neurology (clinical) Neuron medicine.symptom business |
| Zdroj: | Journal of the Neurological Sciences. 197:79-84 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(02)00034-5 |
| Popis: | We report here a combination of rare neurological manifestations of primary Sjögren syndrome (SS), such as motor-dominant motor weakness of peripheral origin, cerebellar ataxia and depression, in a Japanese female patient. An autoantibody in her serum and cerebrospinal fluid immunolabelled spinal motor neurons and cerebellar Purkinje cells. On Western blot, this antibody reacted with a protein of 34 kDa from the extract of spinal cord, dorsal root ganglion, or cerebellar cortex, which might correspond to motor weakness and cerebellar ataxia, respectively. The absence of its reactivity to the liver tissue indicates that this autoantibody targets an antigen represented exclusively in the neural tissues. Although it remains to be proved how autoantibodies, sometimes associated with SS, are involved in the development of clinical pictures, some of them are present in the cerebrospinal fluid and exhibit an exclusive affinity to neural tissues, which indicates its plausible link to neurological manifestations. Recognition of these antineuronal antibodies in SS will potentially provide a chance to treat these patients by removing or inactivating the antibody. |
| Databáze: | OpenAIRE |
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