| Autor: |
Joely Kaufman, Jeremy B. Green, Alex Cazzaniga, David J. Canty, Erin Tims, Jacob Waugh |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 48(11) |
| ISSN: |
1524-4725 |
| Popis: |
One-third of U.S. adults are bothered by excessive sweating and 5% suffer from hyperhidrosis, both of which negatively affect quality-of-life (QoL). A single-use disposable patch using the novel targeted alkali thermolysis (TAT) technology is being developed to address this condition.Assess the efficacy and safety of the TAT patch for the treatment of excessive sweating using a randomized, double-blind, sham-controlled study design.Adults with Hyperhidrosis Disease Severity Scale (HDSS) scores of 3 or 4 ( n = 16) were treated with an active or sham patch for up to 3 minutes (as established in a previous unpublished feasibility study) and evaluated weekly for 6 weeks post-treatment. The primary effectiveness measure was improved HDSS at Week-4.The study met its objective. For the primary efficacy measure, 83% of TAT-treated subjects reported HDSS scores of 1 or 2 at Week-4 versus 0% of sham-treated subjects ( p = .0032). Furthermore, 67% of TAT-treated subjects had a 2-point improvement in HDSS scores versus 0% of sham-treated subjects ( p = .0123). Quality-of-life improvement correlated with HDSS. The TAT patch seemed to be well-tolerated; one transient moderate adverse event that resolved without sequelae was reported.The TAT patch successfully demonstrated efficacy and was well-tolerated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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