Dopamine D1 receptor signalling in the lateral shell of the nucleus accumbens controls dietary fat intake in male rats
| Autor: | Tess Kool, Charlene Diepenbroek, Joram D. Mul, Michel Barrot, Susanne E la Fleur, Anil Joshi, Leslie Eggels, Laura L Koekkoek, Andries Kalsbeek |
|---|---|
| Přispěvatelé: | Structural and Functional Plasticity of the nervous system (SILS, FNWI), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratory for Endocrinology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Endocrinology, Graduate School, Netherlands Institute for Neuroscience (NIN) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Nucleus accumbens Rats Sprague-Dawley Fat and sugar intake 03 medical and health sciences 0302 clinical medicine Dopamine receptor D1 Dopamine Internal medicine Dopamine receptor D2 medicine Animals Dopamine receptors Receptor General Psychology 030304 developmental biology Raclopride 0303 health sciences Nutrition and Dietetics Receptors Dopamine D2 Chemistry Receptors Dopamine D1 Antagonist Dietary Fats Rats Endocrinology Dopamine receptor Rat [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Obesogenic diet 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Appetite, 167:105597. Academic Press Inc. Appetite Appetite, Elsevier, 2021, 167, pp.105597. ⟨10.1016/j.appet.2021.105597⟩ Appetite, 167. Academic Press |
| ISSN: | 0195-6663 1095-8304 |
| DOI: | 10.1016/j.appet.2021.105597⟩ |
| Popis: | Central dopamine signaling regulates reward-related aspects of feeding behavior, and during diet-induced obesity dopamine receptor signaling is altered. Yet, the influence of dopamine signaling on the consumption of specific dietary components remains to be elucidated. We have previously shown that 6-hydroxydopamine-mediated lesions of dopamine neuron terminals in the lateral shell of the nucleus accumbens promotes fat intake in rats fed a multi-component free-choice high-fat high-sugar (fcHFHS) diet. It is however not yet determined which dopamine receptors are responsible for this shift towards fat preference. In this study, we assess the effects of D1-or D2 receptor acute inhibition in the lateral shell of the nucleus accumbens on fcHFHS diet consumption. We report that infusion of the D1 receptor antagonist SCH2 3390, but not the D2 receptor antagonist raclopride, promotes dietary fat consumption in male Sprague Dawley rats on a fcHFHS diet during 2 h after infusion. Furthermore, anatomical analysis of infusion sites revealed that the rostral region, but not the caudal region, of the lateral shell of the nucleus accumbens is sensitive to the D1 receptor inhibition effects on fat consumption. Our data highlight a role for D1 receptors in the rostral region of the lateral shell of the nucleus accumbens to control dietary fat consumption. |
| Databáze: | OpenAIRE |
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