Immunogenicity of Poliomyelitis Vaccine Prepared with Ultraviolet Irradiation and Mild Heat

Autor:	John L. Neal, Martha Janota, Franz Oppenheimer, Howard J. Shaughnessy, Albert M. Wolf, Richard A. Morrissey, Albert Milzer, Henry Naftulin
Rok vydání:	1957
Předmět:	Poliomyelitis vaccine Vaccines Antigenicity Hot Temperature Ultraviolet Rays Immunogenicity Biology Virology Ultraviolet therapy General Biochemistry Genetics and Molecular Biology Virus Microbiology Tissue culture Antibody Formation Humans Potency Ultraviolet Therapy Irradiation Poliomyelitis
Zdroj:	Experimental Biology and Medicine. 95:251-255
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-95-23184
Popis:	Summary1. Poliomyelitis virus of high titer in the form of a freshly filtered tissue culture preparation, can be inactivated by ultraviolet irradiation in centrifugal filmers. 2. Inactivation of the virus preparations by a combination of ultraviolet irradiation and exposure to mild heat for several days yields vaccine of good potency. In this procedure there is a margin of safety between complete inactivation and appreciable loss of antigenicity. 3. Experience thus far indicates a degree of consistency and reproducibility for the method described. 4. Vaccines made by a combination of ultraviolet irradiation and mild heat appear to retain their antigenicity for at least 7 months.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8366612e85493100a559719cee7ae54a https://doi.org/10.3181/00379727-95-23184 Zobrazit plný text záznamu