Inventory of molecular markers affecting biological characteristics of avian influenza A viruses
Autor: | Paul F. Horwood, Erik A. Karlsson, Yi-Mo Deng, Andrew R. Greenhill, Annika Suttie, Philippe Dussart |
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Přispěvatelé: | Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Federation University [Churchill, Australia], The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, James Cook University (JCU), This publication is the result, in part, of work conducted under a cooperative agreement with the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services (HHS), grant number IDSEP140020-01-00 awarded to Dr. Philippe Dussart and Dr. Erik Karlsson. Its contents and conclusions are solely the responsibility of the authors and do not represent the official views of HHS. Annika Suttie is funded by an Australian Government Research Training Program Scholarship and a Faculty of Science and Technology Research Scholarship from Federation University. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health., The authors would like to thank all of the members of the Influenza Team in the Virology Unit at the Institute Pasteur in Cambodia, as well as at the WHO Collaborating Center and Peter Doherty Institute at the University of Melbourne for their insightful discussions and input. |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
animal diseases
Avian influenza Molecular marker MESH: Genetic Markers medicine.disease_cause Influenza A Virus H7N9 Subtype Poultry chemistry.chemical_compound Medical microbiology MESH: Poultry Zoonoses Pandemic MESH: Animals Risk assessment 0303 health sciences Review Paper MESH: Influenza A Virus H7N9 Subtype MESH: Drug Resistance Viral Zoonotic Infection Transmission (medicine) MESH: Influenza Human virus diseases General Medicine 3. Good health MESH: Birds [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology MESH: Zoonoses Genetic Markers medicine.medical_specialty MESH: Pandemics MESH: Influenza A Virus H5N1 Subtype Sequencing data Biology Birds 03 medical and health sciences MESH: Influenza in Birds Virology Drug Resistance Viral Influenza Human Genetics medicine Animals Humans [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Molecular inventory Molecular Biology Pandemics 030304 developmental biology MESH: Humans Influenza A Virus H5N1 Subtype 030306 microbiology Pathogenicity Influenza A virus subtype H5N1 chemistry Influenza in Birds Mutation Influenza virus |
Zdroj: | Virus Genes Virus Genes, Springer Verlag, 2019, 55 (6), pp.739-768. ⟨10.1007/s11262-019-01700-z⟩ |
ISSN: | 0920-8569 1572-994X |
Popis: | International audience; Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9. |
Databáze: | OpenAIRE |
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