Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

Autor: Paul F. Horwood, Erik A. Karlsson, Yi-Mo Deng, Andrew R. Greenhill, Annika Suttie, Philippe Dussart
Přispěvatelé: Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Federation University [Churchill, Australia], The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, James Cook University (JCU), This publication is the result, in part, of work conducted under a cooperative agreement with the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services (HHS), grant number IDSEP140020-01-00 awarded to Dr. Philippe Dussart and Dr. Erik Karlsson. Its contents and conclusions are solely the responsibility of the authors and do not represent the official views of HHS. Annika Suttie is funded by an Australian Government Research Training Program Scholarship and a Faculty of Science and Technology Research Scholarship from Federation University. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health., The authors would like to thank all of the members of the Influenza Team in the Virology Unit at the Institute Pasteur in Cambodia, as well as at the WHO Collaborating Center and Peter Doherty Institute at the University of Melbourne for their insightful discussions and input.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
animal diseases
Avian influenza
Molecular marker
MESH: Genetic Markers
medicine.disease_cause
Influenza A Virus
H7N9 Subtype
Poultry
chemistry.chemical_compound
Medical microbiology
MESH: Poultry
Zoonoses
Pandemic
MESH: Animals
Risk assessment
0303 health sciences
Review Paper
MESH: Influenza A Virus
H7N9 Subtype
MESH: Drug Resistance
Viral
Zoonotic Infection
Transmission (medicine)
MESH: Influenza
Human
virus diseases
General Medicine
3. Good health
MESH: Birds
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
MESH: Zoonoses
Genetic Markers
medicine.medical_specialty
MESH: Pandemics
MESH: Influenza A Virus
H5N1 Subtype
Sequencing data
Biology
Birds
03 medical and health sciences
MESH: Influenza in Birds
Virology
Drug Resistance
Viral
Influenza
Human
Genetics
medicine
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
Molecular inventory
Molecular Biology
Pandemics
030304 developmental biology
MESH: Humans
Influenza A Virus
H5N1 Subtype
030306 microbiology
Pathogenicity
Influenza A virus subtype H5N1
chemistry
Influenza in Birds
Mutation
Influenza virus
Zdroj: Virus Genes
Virus Genes, Springer Verlag, 2019, 55 (6), pp.739-768. ⟨10.1007/s11262-019-01700-z⟩
ISSN: 0920-8569
1572-994X
Popis: International audience; Avian influenza viruses (AIVs) circulate globally, spilling over into domestic poultry and causing zoonotic infections in humans. Fortunately, AIVs are not yet capable of causing sustained human-to-human infection; however, AIVs are still a high risk as future pandemic strains, especially if they acquire further mutations that facilitate human infection and/or increase pathogenesis. Molecular characterization of sequencing data for known genetic markers associated with AIV adaptation, transmission, and antiviral resistance allows for fast, efficient assessment of AIV risk. Here we summarize and update the current knowledge on experimentally verified molecular markers involved in AIV pathogenicity, receptor binding, replicative capacity, and transmission in both poultry and mammals with a broad focus to include data available on other AIV subtypes outside of A/H5N1 and A/H7N9.
Databáze: OpenAIRE
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