IL6 genetic variants haplotype is associated with susceptibility and disease activity but not with therapy response in patients with inflammatory bowel disease
| Autor: | Andréa Name Colado Simão, Camila Cataldi de Alcantara, Tamires Flauzino, Cláudia Junko Inoue, Talita Cristina Galvão, Lucilene Rosa, Marcell Alysson Batisti Lozovoy, Beatriz Piantoni Gonçalves, Edna Maria Vissoci Reiche, Silva Westmore, Paula Kikuchi Miyazaki, Jaqueline Costa Castardo de Paula |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Disease Polymorphism Single Nucleotide Inflammatory bowel disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Crohn Disease Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Crohn's disease Interleukin-6 business.industry Haplotype Hepatology Inflammatory Bowel Diseases medicine.disease Ulcerative colitis Haplotypes 030220 oncology & carcinogenesis Colitis Ulcerative 030211 gastroenterology & hepatology Tumor necrosis factor alpha business |
| Zdroj: | International Journal of Colorectal Disease. 36:383-393 |
| ISSN: | 1432-1262 0179-1958 |
| Popis: | The aim of the present study was to evaluate the IL6 −174 G>C (rs1800795) and −572 G>C (rs1800796) genetic variants and their association with inflammatory bowel diseases (IBDs), disease activity, and response to TNF-α inhibitors. The study included 178 patients with IBD and 224 healthy controls. Among the IBD patients, 66 of them were in use of TNF-α inhibitors therapy and were followed during 48 weeks and categorized as responders and non-responders. In total, 89 (50.0%) had ulcerative colitis (UC) and 89 (50.0%) had Crohn’s disease (CD). The IL6 −572 CC genotype presented a protective effect in CD patients in codominant and recessive models, while the IL6 −174 CC genotype was associated with susceptibility to UC and CD. The presence of G/C haplotype in the recessive model (GCGC) was associated with UC. The Crohn’s disease endoscopic index of severity was low in those patients carrying the GCGC haplotype. It was observed that there was no association between the IL6 genetic variants and TNF-α inhibitor therapy response. The G/C haplotype (recessive model) was associated with susceptibility to UC but not to CD. However, the G/C haplotype (dominant model) was associated with the endoscopic activity of CD. Moreover, these IL6 variants did not predict the TNF-α inhibitor therapy response. |
| Databáze: | OpenAIRE |
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