T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10
Autor: | Ahmet Dogan, Ming-Qing Du, Renzo Ranaldi, Rifat Hamoudi, Peter G. Isaacson, Hongtao Ye, Italo Bearzi, Hongxiang Liu |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Oncogene Proteins Fusion Immunology Chromosome Disorders Biology Biochemistry Translocation Genetic immune system diseases Stomach Neoplasms hemic and lymphatic diseases medicine Humans RNA Messenger B cell Adaptor Proteins Signal Transducing Aged Chromosome Aberrations Chromosomes Human Pair 11 Nuclear Proteins MALT lymphoma Cell Biology Hematology Lymphoma B-Cell Marginal Zone Helicobacter pylori Middle Aged medicine.disease biology.organism_classification B-Cell CLL-Lymphoma 10 Protein BCL10 Lymphoma Neoplasm Proteins MALT1 medicine.anatomical_structure Cancer research Disease Progression Female Gastritis medicine.symptom Chromosomes Human Pair 18 Diffuse large B-cell lymphoma Biomarkers |
Zdroj: | Blood. 98(4) |
ISSN: | 0006-4971 |
Popis: | The development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, low-grade tumors, and high-grade tumors. The molecular events underlying this progression are largely unknown. However, identification of the genes involved in MALT lymphoma-specific t(11;18)(q21;q21) and t(1;14)(p22;q32) has provided fresh insights into the pathogenesis of this disease. T(11;18)(q21;q21) results in a chimeric transcript between the API2 and the MALT1 genes, whereas t(1;14) (p22;q32) causes aberrant nuclear BCL10 expression. Significantly, nuclear BCL10 expression also occurs frequently in MALT lymphomas without t(1;14)(p22;q32), suggesting an important role for BCL10 in lymphoma development. Thirty-three cases of H pylori gastritis, 72 MALT lymphomas, and 11 mucosal diffuse large B-cell lymphomas (DLBCL) were screened for t(11;18)(q21;q21) by reverse transcription-polymerase chain reaction followed by sequencing. BCL10 expression in lymphoma cases was examined by immunohistochemistry. The API2--MALT1 fusion transcript was not detected in H pylori gastritis and mucosal DLBCL but was found in 25 of 72 (35%) MALT lymphomas of various sites. Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas. Of the gastric cases, the largest group studied, the frequency of both t(11;18)(q21;q21) and nuclear BCL10 expression was significantly higher in tumors that showed dissemination to local lymph nodes or distal sites (14 of 18 = 78% and 14 of 15 = 93%, respectively) than those confined to the stomach (3 of 29 = 10% and 10 of 26 = 38%). Furthermore, t(11;18)(q21;q21) closely correlated with BCL10 nuclear expression. These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other. (Blood. 2001;98:1182-1187) |
Databáze: | OpenAIRE |
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