Diabetes mellitus: discrimination between single locus and muItifactorial models of inheritance
| Autor: | Chin S. Chung, Madeleine J. Goodman |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Adolescent Genes Recessive Biology Diabetes mellitus Diabetes Mellitus Genetics medicine Humans Child Genetics (clinical) Genes Dominant Dominance (genetics) Phenocopy Age Factors Chromosome Mapping Infant Complex segregation analysis Heritability medicine.disease Major gene Penetrance Meiosis Phenotype Child Preschool Multifactorial Inheritance |
| Zdroj: | Clinical Genetics. 8:66-74 |
| ISSN: | 1399-0004 0009-9163 |
| DOI: | 10.1111/j.1399-0004.1975.tb01956.x |
| Popis: | Family data from 6,559 diabetic propositi were analyzed using the method of complex segregation analysis in an attempt to discriminate the two models of two-allele single-locus inheritance and multifactorial inheritance for early, middle, and late onset diabetes. The three parameters in the single locus model were: degree of dominance, penetrance, and proportion of phenocopies. In early onset diabetes, the heritability estimated from the multifactorial model was so high as to indicate major gene action. In middle and late onset diabetes, best fitting singlelocus models were found to explain the data as well as the multifactorial model. |
| Databáze: | OpenAIRE |
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