Evaluation of the mutagenicity of 'pan masala', a chewing substitute widely used in India
| Autor: | Shreekant V. Gokhale, Ulhas K. Ganu, Rajani A. Bhisey, Aparna N. Bagwe |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Salmonella typhimurium
endocrine system Salmonella India Toxicology medicine.disease_cause Ames test chemistry.chemical_compound Genetics medicine Food science Sodium nitrite Areca Biotransformation Chloroform Plants Medicinal Sodium Nitrite Mutagenicity Tests Pan masala fungi food and beverages Hydrogen-Ion Concentration chemistry Biochemistry Nitrosation Mutation Microsome |
| Zdroj: | Mutation research. 241(4) |
| ISSN: | 0027-5107 |
| Popis: | Mutagenicity of polar and non-polar extracts of a popular brand of ‘pan masala’ was examined using the Salmonella/mammalian microsome test (Ames assay) and 2 tester strains of Salmonella typhimurium , TA98 and TA100. These extracts were also subjected to pretreatment with sodium nitrite at acidic pH, to simulate conditions for endogenous nitrosation. The equeous, aqueous: ethanolic and chloroform extracts as well as their nitrosated mixtures were non-mutagenic in the Ames assay, in the presence and absence of metabolic activation. Only the ethanolic extract elicited a weak mutagenic response in strain TA98 without metabolic activation demonstrating the presence of direct-acting frameshift mutagens in ‘pan masala’. |
| Databáze: | OpenAIRE |
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