Reliability of diagnostic tests for Helicobacter pylori infection
| Autor: | Stefan Redéen, Fredrik Petersson, Kurt Borch, H. Levander, E. Törnkrantz, Erik Mårdh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Medicin och hälsovetenskap Article Subject diagnosis Population Rapid urease test specificity Gastroenterology Medical and Health Sciences Serology Internal medicine Biopsy medicine lcsh:RC799-869 education Accuracy Breath test education.field_of_study Hepatology medicine.diagnostic_test biology business.industry gold standard Diagnostic test Gold standard (test) Helicobacter pylori biology.organism_classification Surgery sinsitivity diagnostic test lcsh:Diseases of the digestive system. Gastroenterology business H. pylori Research Article |
| Zdroj: | Gastroenterology Research and Practice, Vol 2011 (2011) Gastroenterology Research and Practice |
| Popis: | Introduction.Helicobacter pylori (H. pylori)infection is very common worldwide. A reliable diagnosis is crucial for patients withH. pylori-related diseases. At followup, it is important to confirm that eradication therapy has been successful. There is no established gold standard for the diagnosis ofH. pyloriinfection.Material and Methods. A sample of 304 volunteers from the general population was screened forH. pyloriinfection with serology,13C-urea breath test (UBT), rapid urease test (RUT) on fresh biopsy, culture from biopsy, and histological examination. Culture was used as gold standard.Results. The sensitivity was 0.99 for serology, 0.90 for UBT, 0.90 for RUT, and 0.90 for histological examination. Corresponding specificities were 0.82, 0.99, 0.98, and 0.97, respectively. The accuracy was 0.86 for serology, 0.96 for UBT, 0.95 for RUT, 0.93 for culture, and 0.95 for histology. There was a strong correlation between the results of UBT and the histological scores ofH. pyloricolonisation as well as between the results of UBT and the scores of RUT.Conclusion. There were only minor differences in accuracy between the three invasive tests forH. pyloriinfection in this population. RUT may be recommended as the first choice since a result is obtained within hours. The accuracy of UBT was comparable to the invasive tests, and it is recommended for situations when endoscopy is not needed. |
| Databáze: | OpenAIRE |
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