Enalapril plus frusemide MAG3 scintigraphy in hypertensive patients with atherosclerosis and moderate renal insufficiency
| Autor: | J Laedrich, P Weinmann, Georges Baillet, Jean-Luc Moretti, A. Meyrier, P. Buchet, Kleinknecht D, M Caglar, P Le Tourmelin, A Prigent |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Arteriosclerosis Urology Renal function Angiotensin-Converting Enzyme Inhibitors urologic and male genital diseases Renal artery stenosis Renal Artery Obstruction Technetium Tc 99m Mertiatide Enalapril Furosemide medicine.artery medicine Humans Radiology Nuclear Medicine and imaging Renal artery Diuretics Radionuclide Imaging Aged Retrospective Studies Kidney business.industry General Medicine Middle Aged medicine.disease Surgery Stenosis medicine.anatomical_structure Hypertension Kidney Failure Chronic Radiopharmaceuticals business medicine.drug Kidney disease Glomerular Filtration Rate |
| Zdroj: | Nuclear medicine communications. 19(12) |
| ISSN: | 0143-3636 |
| Popis: | We performed a retrospective study on 26 patients with moderate renal failure (mean GFR = 51 +/- 21 ml min-1 1.73 m-2), hypertension and atherosclerosis. Apart from three patients who had completely normal renal Doppler ultrasonography, all patients underwent renal angiography. Three groups of kidneys with different atherosclerotic renal artery involvement were identified: Group 1, 24 kidneys with no renal artery stenosis (RAS); Group 2, 18 kidneys with mild (25% and50% diameter) RAS; and Group 3, 10 kidneys with moderate (50% diameter) RAS. We used a two-day protocol with frusemide plus enalapril 99Tcm-MAG3 scintigraphy. The mean parenchymal transit time (MPTT), time to the maximum activity (time to peak) of the renal curve (Tmax), residual activity and split renal uptake were evaluated. The measured parameters did not differ before and after enalapril in Group 1 or in Group 2. In Group 3, MPTT and residual activity differed significantly (P0.025) before and after enalapril. The Tmax before and after enalapril, MPTT before and after enalapril and residual activity after enalapril differed significantly (P0.05) between Groups 1 and 3 and between Groups 2 and 3. Threshold values were obtained to maximize diagnostic accuracy. The Tmax, MPTT and residual activity after enalapril gave satisfactory results, and MPTT performed best with a 75% positive predictive value and a 98% negative predictive value for the diagnosis of renal artery stenosis. We conclude that MPTT, measured after enalapril administration, is a useful parameter to detect renal artery stenosis in patients with hypertension, atherosclerosis and moderate renal insufficiency. |
| Databáze: | OpenAIRE |
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