Reduced Interferon γ Production and Soluble CD14 Levels in Early Life Predict Recurrent Wheezing by 1 Year of Age
| Autor: | Anne L. Wright, I. Carla Lohman, Stefano Guerra, Marilyn Halonen, Fernando D. Martinez |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lipopolysaccharide Receptors Critical Care and Intensive Care Medicine Severity of Illness Index Cohort Studies Interferon-gamma Predictive Value of Tests Recurrence Internal medicine Intensive care Severity of illness Confidence Intervals Odds Ratio Humans Medicine Longitudinal Studies Sex Distribution Risk factor Respiratory Sounds Asthma business.industry Incidence Incidence (epidemiology) Age Factors Infant Newborn Infant Odds ratio Prognosis medicine.disease Quartile Child Preschool Immunology Female business Biomarkers Cohort study |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 169:70-76 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.200304-499oc |
| Popis: | It is unknown whether reduced production of IFNgamma in early life, before any lower respiratory tract illness, is a risk factor for recurrent wheezing in infancy. We followed 238 infants prospectively from birth to 1 year of age. At birth and at 3 months of age, IFNgamma production from polyclonally stimulated peripheral blood mononuclear cells and soluble CD14 (sCD14) levels in plasma were measured. The odds of developing recurrent wheezing (assessed by questionnaire) in the first year of life were up to 4.5 times higher for children in the lowest quartile of IFNgamma production at 3 months (p = 0.0005) and 3.2 times higher for children in the lowest quartile of sCD14 levels at birth (p = 0.004) as compared with children in the other 3 combined quartiles of IFNgamma and sCD14, respectively. Findings were confirmed in the multivariate analysis. IFNgamma production at 3 months and sCD14 levels at birth were correlated (r = 0.188, p = 0.031). Our findings from a longitudinal cohort suggest that impaired IFNgamma production at 3 months and reduced plasma-sCD14 levels at birth significantly increase the risk of developing recurrent wheezing in the first year of life. |
| Databáze: | OpenAIRE |
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