Plasma B-type natriuretic peptide in dialyzed patients: marker of cardiovascular disease or link to plasma refilling
| Autor: | Doriana Chiarinotti, Martino De Leo, Maddalena Brustia, Paola David, Mariangela De Maria, Carlo Navino, Federica Capurro, Giorgio Bellomo, Laura Ciardi, Andreana De Mauri, Carlo Edoardo Ruva |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Blood volume Hemodiafiltration Left ventricular hypertrophy Gastroenterology chemistry.chemical_compound Internal medicine Diabetes mellitus Troponin I Renin–angiotensin system Natriuretic Peptide Brain Renin Weight Loss Natriuretic peptide Diabetes Mellitus Medicine Humans Aldosterone Fluid Shifts Aged Aged 80 and over Blood Volume business.industry Extracellular Fluid Middle Aged medicine.disease Blood pressure C-Reactive Protein chemistry Nephrology Cardiovascular Diseases Kidney Failure Chronic Female business Biomarkers |
| Zdroj: | Journal of nephrology. 24(4) |
| ISSN: | 1724-6059 |
| Popis: | BACKGROUND B-type natriuretic peptide (BNP) is released in response to extracellular volume and blood pressure (BP) overload and is a risk factor for cardiovascular diseases (CVD). BNP is increased in dialyzed patients (HDpts). The aim of this study was to evaluate the relationships between BNP and renin, aldosterone and blood volume reduction rate (BV/WL), with the presence of CVD and mortality. METHODS Fifty-one HDpts aged 70 ± 14 years were enrolled. BP, BV/WL, BNP, aldosterone, renin, C-reactive protein (CRP), troponin I and routine biochemistry were measured. According to the predialytic plasma BNP levels, the patients were divided into group A with higher BNP and group B with lower BNP than the median value of 330 pg/mL. Follow-up was 1 year. RESULTS After HD, plasma BNP (449.6 ± 582.2 pg/mL vs. 264.1 ± 269.8 pg/mL, p=0.0008) and aldosterone (421.8 ± 573.4 pg/mL vs. 265.1 ± 566.2 pg/mL, p=0.0003) decreased, but not rennin. BNP decreased more after hemodiafiltration than after standard HD (-55.1% ± 28.5% vs. -26.5% ± 19.5%, p=0.002). Patients in group A exhibited more diabetes (58% vs. 28%, p=0.03), ischemic heart disease (42% vs. 16%, p=0.04), left ventricular hypertrophy (88.8% vs. 33.3%, p |
| Databáze: | OpenAIRE |
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