Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis
| Autor: | C. Maingueneau, F. Huet, J.-L. Nivelon, A. Charavel, D. Semama |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Vitamin
medicine.medical_specialty Adolescent Cystic Fibrosis genetic structures medicine.medical_treatment Physiology Poison control Cystic fibrosis chemistry.chemical_compound Internal medicine medicine Humans Prospective Studies Child Vitamin A Prospective cohort study Vision Ocular Vitamin A Deficiency business.industry Carotene Retinol Darkness medicine.disease Adaptation Physiological Vitamin A deficiency Retinol binding protein Endocrinology chemistry Pediatrics Perinatology and Child Health Linear Models business |
| Zdroj: | European Journal of Pediatrics. 156:949-951 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s004310050749 |
| Popis: | The aim of this study was to document plasma retinol status and nocturnal vision in ten eutrophic adolescents with cystic fibrosis (CF) receiving daily retinol supplementation. Plasma retinol, alpha and beta carotenes and retinol binding protein were measured in ten clinically stable CF patients (mean age: 14.3 years; Shwachman score: 80-100). Nocturnal vision evaluation was performed with a Beyne optometer. Plasma retinol (mean 0.42 +/- 0.16 mg/l), alpha carotene and beta carotene levels were below the lower limit of normal in all but one patient. Five out of ten patients with normal standard opthalmological examination presented a poor (n = 3 patients) or a pathological (n = 2) dark adaptation test. These two patients showed a dramatic increase in nocturnal vision after 1 year of adapted retinol supplementation.Low vitamin A levels occur frequently in clinically stable, eutrophic and retinol supplemented CF adolescents. Since vitamin A deficiency is associated with poor nocturnal vision and since this pattern can be reversed by adapted retinol supplementation, we recommend monitoring plasma vitamin A levels in CF patients and evaluation of dark adaptation in retinol deficient patients. |
| Databáze: | OpenAIRE |
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