Skull Base Fungal Osteomyelitis: A Case Report and Review of the Literature
| Autor: | Pasquale Capriglione, Andrea Elefante, Elena Cantone, Walter Del Vecchio, Gaetano Motta, Giusy Grimaldi, Antonella Miriam Di Lullo, Maurizio Iengo, Camilla Russo, Michele Cavaliere |
|---|---|
| Přispěvatelé: | Di Lullo, A. M., Russo, C., Grimaldi, G., Capriglione, P., Cantone, E., del Vecchio, W., Motta, G., Iengo, M., Elefante, A., Cavaliere, M., Di Lullo, Antonella M., Russo, Camilla, Grimaldi, Giusy, Capriglione, Pasquale, Cantone, Elena, del Vecchio, Walter, Motta, Gaetano, Iengo, Maurizio, Elefante, Andrea, Cavaliere, Michele |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty malignant otitis externa Candida parapsilosis Facial Paralysis ear symptom Disease Skull base osteomyelitis Malignant otitis externa medicine.disease_cause Diagnosis Differential Medical Illustration Humans Medicine magnetic resonance imaging Stage (cooking) Aged 80 and over Skull Base biology business.industry Pseudomonas aeruginosa Candidiasis Osteomyelitis computed tomography biology.organism_classification Dermatology Skull medicine.anatomical_structure Otorhinolaryngology Etiology Skull Base Fungal Osteomyelitis skull base osteomyelitis business |
| Zdroj: | Ear, nose, & throat journal (2020). doi:10.1177/0145561320936006 info:cnr-pdr/source/autori:Di Lullo A.M.; Russo C.; Grimaldi G.; Capriglione P.; Cantone E.; del Vecchio W.; Motta G.; Iengo M.; Elefante A.; Cavaliere M./titolo:Skull Base Fungal Osteomyelitis: A Case Report and Review of the Literature/doi:10.1177%2F0145561320936006/rivista:Ear, nose, & throat journal/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| DOI: | 10.1177/0145561320936006 |
| Popis: | Skull base osteomyelitis (SBO) is an invasive infection refractory to therapy, closely linked with malignant otitis externa (MOE). It is characterized by a mild clinical presentation that can delay cross-sectional imaging considered as the key to revealing it. Skull base osteomyelitis typically affects elderly diabetics and immunocompromised patients (>70 years). It most commonly has an otogenic origin due to an extension of MOE. The prognosis can be very poor without the administration of adequate and timely therapy at an early disease stage. Nowadays, Pseudomonas aeruginosa remains the most common pathogen associated with SBO. Fungi are a rare cause of MOE. This report documents a rare case of otogenic SBO caused by Candida parapsilosis in a diabetic patient, with persistent otologic symptoms as clinical onset and resistance to medical treatment. Fungal MOE has more subtle symptoms and is more aggressive than its bacterial counterpart. When MOE is resistant to antibacterial drugs, this should raise the suspicion of a fungal etiology of MOE. The current guidelines do not exhaustively describe the diagnosis, antifungal drugs of choice, and optimum duration of treatment. The description of these rare clinical cases should help with the multidisciplinary management of this disease in order to optimize the diagnosis and therapeutic protocol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|