Accumulation and interactions of β-carotene and α-tocopherol in patients with adenomatous polyps
| Autor: | G Maiani, Giuseppe Pappalardo, AM Conte, Antonio Guadalaxara, R. Bugianesi, Elena Azzini, Sohrab Mobarhan, F Simone |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adenomatous polyps Colon Biopsy medicine.medical_treatment alpha-Tocopherol Medicine (miscellaneous) Placebo Gastroenterology Antioxidants Adenomatous Polyps Statistical significance Internal medicine Humans Medicine Drug Interactions Tissue Distribution In patient Tocopherol Intestinal Mucosa Aged Nutrition and Dietetics medicine.diagnostic_test business.industry Vitamin E Carotene Middle Aged beta Carotene Colonic Neoplasms Dietary Supplements Female business |
| Zdroj: | European Journal of Clinical Nutrition. 56:546-550 |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/sj.ejcn.1601354 |
| Popis: | Objective: The aims of the present study were: (1) to determine whether short-term supplementation of β-carotene (BC) or vitamin E (VE; α-tocopherol) would result in their respective accumulation in normal colonic mucosa and in adenomatous polyps; (2) to determine whether the intake of BC would interfere with the concentration of VE in these target tissues. Design: Blood and colonic biopsy samples were taken before and after supplementation. Subjects: Eighteen volunteers with colonic adenomatous polyps were enrolled into this study. Interventions: The supplementation lasted for 43 days and patients were examined over the whole period. Subjects were randomised into four groups according to the four different supplementations: placebo, natural BC (25 000 IU/day), natural VE (400 IU/day), combination BC/VE. Results: Initially we were aiming for recruitment of 20 patients in each group, however after 2 y of study (1997–1999), we terminated the study because of slow recruitment and analysed the data. In placebo subjects after supplementation, the plasma concentrations of BC and VE remained unchanged, however only two patients were recruited in this group and therefore we did not include this group in our final analysis. In BC group, the plasma BC concentrations increased significantly (P |
| Databáze: | OpenAIRE |
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