PNET/ESFT of the cranial vault: a case report
| Autor: | M Fortunato, C Bernucci, V Caldera, Marta Mellai, Davide Schiffer, A Comino |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
CD99
Vimentin 12E7 Antigen Pathology and Forensic Medicine Diagnosis Differential Antigens CD Cranial vault medicine Humans Neuroectodermal Tumors Primitive Vault (organelle) biology Brain Neoplasms business.industry Skull Meninges Cauda equina General Medicine Anatomy Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Neurology Fusion transcript biology.protein Female Neurology (clinical) Differential diagnosis Meningioma business Cell Adhesion Molecules |
| Zdroj: | Web of Science |
| ISSN: | 0722-5091 |
| DOI: | 10.5414/npp29372 |
| Popis: | A case of peripheral PNET (PNET/ESFT) of the cranial vault is described. A 56-year-old woman showed a mass with a large cyst in the right temporal region, adherent to the meninges, which caused a left hemiparesis with headache and confusion. The mass was totally removed. The histological examination showed a dense proliferation of small elements, organized in lobules separated by reticulin septa. Many circumscribed necroses, vessels with a thick handcuff of reticulin, a diffuse mucous degeneration and abundant mitoses were present. The cells were positive for Vimentin and CD99. RT-PCR revealed the EWS/FLI1 fusion transcript of the t(11,22) (q24;q12) translocation. The patient presented is the oldest one of the rare cases of dura-based meningioma-mimicking pPNETs till now described. In line with the possible origin from peripheral nerves or roots of cauda equina of non-intracranial tumors, those of the vault may derive from peripheral sensory nerves of the dura. The differential diagnosis must be made with cPNETs which show a worse prognosis and both can benefit from a different chemotherapy. |
| Databáze: | OpenAIRE |
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