Sensitivity and specificity of MultiColor imaging in detecting proliferative diabetic retinopathy
| Autor: | Sara Vaz-Pereira, Tiago Morais-Sarmento, Gabriella De Salvo |
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| Předmět: |
Fluorescein angiography
medicine.medical_specialty Diabetic macular edema Macular Edema Neovascularization Ophthalmology Diabetes Mellitus Humans Proliferative diabetic retinopathy Medicine Disc neovascularization Original Paper Diabetic Retinopathy medicine.diagnostic_test business.industry Retinal neovascularization Diabetic retinopathy medicine.disease MultiColor imaging eye diseases Confidence interval Vitreous hemorrhage Diagnostic imaging medicine.symptom Epiretinal membrane business Tomography Optical Coherence |
| Zdroj: | Web of Science International Ophthalmology |
| Popis: | Purpose To evaluate the accuracy of MultiColor imaging (MC) compared to fluorescein angiography (FA) in detecting proliferative diabetic retinopathy (PDR) and associated diabetic retinopathy features. Methods Fifty-nine eyes from 38 PDR patients were included. MC images were reviewed by 2 independent masked graders. A qualitative analysis based on the following features was performed: neovascular complexes (NVC), disc neovascularization (NVD), neovascularization elsewhere (NVE), microaneurysm (MA), intraretinal hemorrhage (IRH), vitreous hemorrhage (VH), preretinal hemorrhage (PRH), fibrosis, hard exudates (HE), epiretinal membrane (ERM), diabetic macular edema (DME), ischemia and laser spots (LS). Measures of diagnostic accuracy compared to FA were determined. Results The sensitivity for the detection of NVC using MC was 95.1%, with a specificity of 40.0%, positive predictive value (PPV) of 92.9% and negative predictive value (NPV) of 50.0%. Sensitivity and specificity were higher in detecting NVD (88.9% and 76.9%) while NVE registered higher PPV (88.9%). MC was highly sensitive in detecting IRH, HE, ERM and LS (100%), MA (98.0%) and fibrosis (95.5%). Highest specificity was found for VH (100.0%), DME (100.0%), PRH (98.1%) and LS (89.5%). The area under the receiver-operating characteristic analysis of MC was excellent in NVD (0.83, 95% confidence interval (CI), 0.71–0.95, p |
| Databáze: | OpenAIRE |
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