The effect of the platelet-rich plasma on osteogenic potential of the periosteum in an animal bone defect model
| Autor: | Meriç Çirpar, Önder Bozdoğan, Birhan Oktaş, Elif Şanlı, İbrahim Deniz Canbeyli |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Fracture healing Bone healing Bone tissue Fibrin Rats Sprague-Dawley Osteogenesis Precursor cell Periosteum Medicine Animals Orthopedics and Sports Medicine biology business.industry Platelet-Rich Plasma Rehabilitation Tissue Graft Rats Disease Models Animal medicine.anatomical_structure Platelet-rich plasma biology.protein Surgery Original Article business Animal bone |
| Zdroj: | Joint Diseases and Related Surgery |
| ISSN: | 2687-4792 |
| Popis: | OBJECTIVES This study aims to investigate whether plasma-rich plasma (PRP) enhances the osteogenic potential of periosteal grafts used to repair bone defects and maintains both histologically and biomechanically more durable bone tissue. MATERIALS AND METHODS A standard bone defect was formed to the left femurs of 54 Sprague-Dawley rats and three groups were formed. In the first group (n=18), no periosteal repair was done for bone defect. In the second group (n=18), periosteal graft tissue was sutured to cover the defect entirely. In the third group (n=18), before periosteal repair, a 1 mL of PRP fibrin was applied into the bone defect. All femoral specimens were compared histologically at four and six weeks and biomechanically by three-point bending test at six weeks after treatment. RESULTS In the PRP applied group, healing of the bone defect at four weeks was significantly better than the other groups in terms of histological new bone formation (p |
| Databáze: | OpenAIRE |
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