Histologic Variation in the Skin Lesions of the Glucagonoma Syndrome
| Autor: | Sonia M. Kheir, Emily F. Omura, Inchul Lee, William E. Grizzle, Guillermo A. Herrera |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Pathology medicine.medical_specialty Pancreatic disease Glucagonoma Skin Diseases Glucagon Pathology and Forensic Medicine Necrosis Pancreatic tumor Humans Medicine Pancreas Skin Glucagonoma Syndrome Hyperplasia integumentary system medicine.diagnostic_test business.industry Syndrome Middle Aged Necrolytic migratory erythema Adenoma Islet Cell medicine.disease Pancreatic Neoplasms Skin biopsy Female Surgery Anatomy business Skin lesion |
| Zdroj: | The American Journal of Surgical Pathology. 10:445-453 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-198607000-00001 |
| Popis: | Three cases of glucagonoma syndrome were seen in 1 year. Study of the skin biopsies from the first two cases led to a correct diagnosis from skin biopsy of the third case, although it was not suggested clinically. In each case serum glucagon levels were high and a pancreatic tumor was found, with complete remission of symptoms in cases 1 and 3 after resection; case 2 refused surgery and has died. A total of nine skin biopsies from the three patients showed a variety of findings: epidermal necrosis; subcorneal pustules, either isolated or associated with necrosis of the epidermis; confluent parakeratosis, epidermal hyperplasia, and marked papillary dermal angioplasia; and suppurative folliculitis. The clinical lesions in this syndrome vary from bright red macules to annular superficial erosions and flaccid pustules. Similarly, several histopathologic features of the disease can occur, which may represent the progression of the disease. No single histologic feature was specific for the disease, but a combination of the features is probably diagnostic. Therefore, multiple skin biopsies are recommended when this diagnosis is suspected. |
| Databáze: | OpenAIRE |
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