Enhanced Gametocyte Formation in Erythrocyte Progenitor Cells: A Site-Specific Adaptation by Plasmodium falciparum
| Autor: | Nicholas E. Timmins, Gregory S. Watson, Jolanta A. Watson, Marko Guenther, Katharine R. Trenholme, Lars Nielson, Christopher L. Peatey, Christopher L. Brown, Donald L. Gardiner |
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| Rok vydání: | 2013 |
| Předmět: |
Erythrocytes
Stem Cells Cell Membrane Plasmodium falciparum Biology Microscopy Atomic Force biology.organism_classification Elasticity Cell biology Infectious Diseases medicine.anatomical_structure Membrane protein medicine Extracellular Gametocyte Humans Immunology and Allergy Parasite hosting Bone marrow Progenitor cell Stem cell |
| Zdroj: | The Journal of Infectious Diseases. 208:1170-1174 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation. |
| Databáze: | OpenAIRE |
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