Peripheral blood lymphocyte subsets in fleece rot-resistant and -susceptible sheep
| Autor: | McColl Ka, Chin Jc, Gogolewski Rp |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Veterinary medicine Lymphocyte T-Lymphocytes Sheep Diseases macromolecular substances complex mixtures Leukocyte Count medicine Animals Pseudomonas Infections Fluorescent Antibody Technique Indirect B-Lymphocytes Sheep General Veterinary biology Wool technology industry and agriculture food and beverages General Medicine Skin Diseases Bacterial Peripheral blood Lymphocyte Subsets medicine.anatomical_structure Phenotype Peripheral blood lymphocyte Antibody Formation biology.protein Flock Disease Susceptibility Antibody |
| Zdroj: | Australian veterinary journal. 75(6) |
| ISSN: | 0005-0423 |
| Popis: | Objective To compare haematological values and lymphocyte phenotypes in the peripheral blood of fleece rot-resistant and -susceptible sheep. Procedure Experiments were conducted on 2- and 3-year-old Merino rams, flock 1 (17 rams) and flock 2 (32 rams), respectively. Within each flock, individual rams were classified as fleece rot-resistant or -susceptible, based on established criteria. Total and differential white cell counts, and indirect fluorescent antibody tests specific for B cells and T cells were performed on all sheep. The concentration of various subsets of circulating lymphocytes was then determined in each sheep. Results There were no significant differences between fleece rot-resistant and -susceptible sheep from either flock in the mean total or differential white cell counts. However, fleece rot-resistant rams in flock 1 did have a significantly higher concentration of circulating SBU-T1+ cells than fleece rot-susceptible rams from the same flock. No such difference was noted in the rams from flock 2. While all rams in flock 1 were free of clinical fleece rot, 24 rams in flock 2 (comprising all 17 fleece rot-susceptible and 7 of 15 fleece rot-resistant animals) had clinical signs of the disease. Fleece rot-free rams in this flock (irrespective of their classification as fleece rot-resistant or -susceptible) had significantly higher concentrations of circulating SBU-T1+ cells compared with fleece rot-affected animals. They also had significantly higher concentrations of circulating B cells, and total lymphocytes. Conclusions An examination of peripheral blood lymphocyte subsets in fleece rot-resistant and -susceptible sheep revealed a possible association between resistance to fleece rot and the concentration of circulating SBU-T1+ cells. |
| Databáze: | OpenAIRE |
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