Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae
| Autor: | Dominique Decré, Laurence Drieux, Lionel Frangeul, Charlotte Verdet, Fabrice Compain, Guillaume Arlet, Sylvain Brisse |
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| Přispěvatelé: | Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Génopole, Institut Pasteur [Paris], Service de Bactériologie et d'Hygiène Hospitalière [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génomique évolutive des Microbes / Microbial Evolutionary Genomics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), This work was funded in part by the Université Pierre et Marie Curie (Paris, France) and by a grant from the Assistance Publique-Hôpitaux de Paris (contract CRC 08007 [KPath])., Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
MESH: Sequence Analysis
DNA Klebsiella pneumoniae MESH: Klebsiella pneumoniae MESH: beta-Lactamases MESH: Base Sequence Plasmid Drug Resistance Multiple Bacterial Pharmacology (medical) Replicon Genetics 0303 health sciences MESH: R Factors MESH: Microbial Sensitivity Tests Aminoglycoside Nucleic acid sequence MESH: Aminoglycosides Anti-Bacterial Agents 3. Good health Infectious Diseases MESH: DNA Transposable Elements [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Fluoroquinolones Transposable element R Factors Molecular Sequence Data Microbial Sensitivity Tests Biology beta-Lactam Resistance beta-Lactamases Microbiology 03 medical and health sciences Mechanisms of Resistance MESH: Anti-Bacterial Agents [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Gene 030304 developmental biology Pharmacology MESH: Molecular Sequence Data Base Sequence 030306 microbiology Sequence Analysis DNA MESH: Drug Resistance Multiple Bacterial MESH: Fluoroquinolones biochemical phenomena metabolism and nutrition biology.organism_classification MESH: beta-Lactam Resistance Multiple drug resistance Aminoglycosides DNA Transposable Elements MESH: Genes MDR Genes MDR [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] |
| Zdroj: | Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (7), pp.4207-4210. ⟨10.1128/AAC.02773-13⟩ Antimicrobial Agents and Chemotherapy, 2014, 58 (7), pp.4207-4210. ⟨10.1128/AAC.02773-13⟩ |
| ISSN: | 0066-4804 1098-6596 |
| DOI: | 10.1128/AAC.02773-13⟩ |
| Popis: | We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam ( bla DHA-1 , bla SHV-12 ), aminoglycoside ( aphA1 , strA , strB ), and fluoroquinolone ( qnrB4 , aac6′-1b-cr ) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers. |
| Databáze: | OpenAIRE |
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