Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans
| Autor: | Eun-Jeong Choi, Tai-Gyu Kim, Hyoung Shik Shin, Dong-Gyun Lim, In-Cheol Baek, Dong-Hwan Shin, Hyoung-Jae Kim, Haeyoun Choi |
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| Rok vydání: | 2021 |
| Předmět: |
Middle East respiratory syndrome coronavirus
viruses Genes MHC Class II Immunology Short Report Genes MHC Class I Human leukocyte antigen medicine.disease_cause law.invention MERS‐CoV Short Reports MERS law Republic of Korea medicine HLA-DQ beta-Chains Humans Immunology and Allergy Typing Allele Polymerase chain reaction business.industry Mortality rate virus diseases RC581-607 Acquired immune system medicine.disease HLA Middle East respiratory syndrome Immunologic diseases. Allergy business |
| Zdroj: | Immunity, Inflammation and Disease, Vol 10, Iss 1, Pp 111-116 (2022) Immunity, Inflammation and Disease |
| ISSN: | 2050-4527 |
| DOI: | 10.1002/iid3.541 |
| Popis: | Introduction Middle East Respiratory Syndrome (MERS) caused by MERS‐coronavirus (CoV) is a lower respiratory tract disease characterized by a high mortality rate. MERS‐CoV spread from Saudi Arabia to other countries, including South Korea. Dysfunction of the human leukocyte antigen (HLA) system has many effects due to genetic complexity and its role in the adaptive immune response. We investigated the association of HLA class I and II alleles with MERS‐CoV in 32 patients with MERS. Methods HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1, and ‐DPB1 were genotyped by polymerase chain reaction sequence‐based typing. Results HLA‐DQB1*03:02 are significantly associated with moderate/mild cases of MERS‐CoV. Other alleles are no statistical significance. Conclusions Treatment strategies based on current research on the HLA gene and MERS‐CoV will provide potential therapeutic targets. |
| Databáze: | OpenAIRE |
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