Intramyocardial Triglycerides Among Women With vs Without HIV: Hormonal Correlates and Functional Consequences
| Autor: | Magid Awadalla, Takara L. Stanley, Corinne Rivard, Lidia S. Szczepaniak, Adam Rokicki, Lindsay T Fourman, Markella V. Zanni, Virginia A. Triant, Tomas G. Neilan, Connor P. Mulligan, Diana Cagliero, Mabel Toribio, Lauren Stone, Tricia H. Burdo, Jennifer E. Ho, Michael D. Nelson |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Magnetic Resonance Spectroscopy Endocrinology Diabetes and Metabolism Clinical Biochemistry Diastole HIV Infections Context (language use) Biochemistry Asymptomatic Ventricular Function Left chemistry.chemical_compound Endocrinology Risk Factors Internal medicine medicine Humans Triglycerides Clinical Research Articles Aged Heart Failure Ejection fraction Triglyceride business.industry Myocardium Biochemistry (medical) Case-control study Heart Middle Aged medicine.disease Magnetic Resonance Imaging Hormones chemistry Case-Control Studies Heart failure HIV-1 Cardiology Female medicine.symptom Cardiomyopathies business Body mass index |
| Zdroj: | J Clin Endocrinol Metab |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context Women with HIV (WHIV) on anti-retroviral therapy (ART) are living longer but facing heightened vulnerability to heart failure. Objective We investigated metabolic/hormonal/immune parameters relating to diastolic dysfunction—a precursor to heart failure—among WHIV without known cardiovascular disease (CVD). Design and Outcome Measures Nineteen ART-treated WHIV and 11 non-HIV-infected women without known CVD enrolled and successfully completed relevant study procedures [cardiac magnetic resonance spectroscopy (MRS) and cardiac MRI]. Groups were matched on age and body mass index. Primary outcome measures included intramyocardial triglyceride content (cardiac MRS) and diastolic function (cardiac MRI). Relationships between intramyocardial triglyceride content and clinical parameters were also assessed. Results Among WHIV (vs non-HIV-infected women), intramyocardial triglyceride content was threefold higher [1.2 (0.4, 3.1) vs 0.4 (0.1, 0.5)%, P = 0.01], and diastolic function was reduced (left atrial passive ejection fraction: 27.2 ± 9.6 vs 35.9 ± 6.4%, P = 0.007). There was a strong inverse relationship between intramyocardial triglyceride content and diastolic function (ρ = −0.62, P = 0.004). Among the whole group, intramyocardial triglyceride content did not relate to chronologic age but did increase across the reproductive aging spectrum (P = 0.02). HIV status and reproductive aging status remained independent predictors of intramyocardial triglyceride content after adjusting for relevant cardiometabolic parameters (overall model R2 = 0.56, P = 0.003; HIV status P = 0.01, reproductive aging status P = 0.02). Conclusions For asymptomatic WHIV, increased intramyocardial triglyceride content is associated with diastolic dysfunction. Moreover, relationships between intramyocardial triglyceride accumulation and women’s reproductive aging are noted. |
| Databáze: | OpenAIRE |
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