Longitudinal follow-up of health effects among workers handling engineered nanomaterials: a panel study

Autor: Saou-Hsing Liou, Wei-Te Wu, Shu-Li Wang, Tung-Sheng Shih, Lih-Ann Li, Hui-Ling Lee, Tsui-Chun Tsou
Rok vydání: 2019
Předmět:
Male
Health
Toxicology and Mutagenesis
010501 environmental sciences
01 natural sciences
Antioxidants
0302 clinical medicine
Epidemiology
Nanotechnology
panel study
Longitudinal Studies
chemistry.chemical_classification
lcsh:Public aspects of medicine
Glutathione peroxidase
Confounding
follow-up study
Middle Aged
030210 environmental & occupational health
lcsh:Industrial medicine. Industrial hygiene
Population study
Female
Adult
medicine.medical_specialty
Taiwan
lcsh:RC963-969
03 medical and health sciences
Environmental health
Occupational Exposure
medicine
Humans
0105 earth and related environmental sciences
Nanomaterials
Inflammation
Dose-Response Relationship
Drug
Control banding
business.industry
Surrogate endpoint
Public health
Research
Public Health
Environmental and Occupational Health
Repeated measures design
lcsh:RA1-1270
Nanostructures
Oxidative Stress
chemistry
health effect markers
control banding
business
Biomarkers
DNA Damage
Follow-Up Studies
Zdroj: Environmental Health
Environmental Health, Vol 18, Iss 1, Pp 1-17 (2019)
ISSN: 1476-069X
Popis: Background Although no human illness to date is confirmed to be attributed to engineered nanoparticles, occupational epidemiological studies are needed to verify the health effects of nanoparticles. This study used a repeated measures design to explore the potential adverse health effects of workers handling nanomaterials. Methods Study population was 206 nanomaterial-handling workers and 108 unexposed controls, who were recruited from 14 nanotechnology plants. They were followed up no less than two times in four years. A questionnaire was used to collect potential confounders and detailed work conditions. Control banding was adopted to categorize risk level for each participant as a surrogate marker of exposure. Health hazard markers include cardiopulmonary dysfunction markers, inflammation and oxidative damage markers, antioxidant enzymes activity, and genotoxicity markers. The Generalized Estimating Equation model was applied to analyze repeated measurements. Results In comparison to the controls, a significant dose-dependent increase on risk levels for the change of superoxide dismutase (p Conclusions This repeated measurement study suggests that there was no evidence of potential adverse health effects under the existing workplace exposure levels among nanomaterials handling workers, except for the increase of antioxidant enzymes.
Databáze: OpenAIRE
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