Phenotype of Osteosarcopenia in Older Individuals With a History of Falling
| Autor: | Fernando Gomez, Ya Ruth Huo, Susan W. Muir, Oddom Demontiero, Pushpa Suriyaarachchi, Derek Boersma, Piumali Gunawardene, Gustavo Duque, Carmen L. Curcio, Manuel Montero-Odasso |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging Sarcopenia medicine.medical_specialty Time Factors Cross-sectional study Population Osteoporosis Physical examination Comorbidity Risk Assessment Severity of Illness Index Grip strength Absorptiometry Photon Age Distribution Hand strength Prevalence medicine Humans Sex Distribution education Gait Geriatric Assessment General Nursing Aged Aged 80 and over education.field_of_study Hand Strength medicine.diagnostic_test Hip Fractures business.industry Health Policy General Medicine medicine.disease Osteopenia Cross-Sectional Studies Multivariate Analysis Linear Models Physical therapy Accidental Falls Female Geriatrics and Gerontology business Follow-Up Studies |
| Zdroj: | Journal of the American Medical Directors Association. 16:290-295 |
| ISSN: | 1525-8610 |
| Popis: | In older persons, the combination of osteopenia/osteoporosis and sarcopenia has been proposed as a subset of frailer individuals at higher risk of institutionalization, falls, and fractures. However, the particular clinical, biochemical, and functional characteristics of the osteosarcopenic (OS) patients remain unknown. In this study, we used a clinical definition of osteosarcopenia aiming to determine the clinical, functional, and biochemical features that are unique to these patients within a population of older people who fall.Cross-sectional study.Falls and Fractures Clinic, Nepean Hospital (Penrith, NSW, Australia).A total of 680 people (mean age = 79, 65% women) assessed between 2009 and 2013.Assessment included medical history, physical examination, bone densitometry and body composition by dual-energy X-ray absorptiometry, posturography, grip strength, gait parameters (GaitRITE), and blood tests for nutrition and secondary causes of sarcopenia and osteoporosis. Patients were divided into 4 groups: (1) osteopenic (BMD-1.0 SD), (2) sarcopenic, (3) OS, and (4) nonsarcopenic/nonosteopenic. Difference between groups was assessed with 1-way ANOVA and χ(2) analysis. Multivariable linear regression evaluated the association between the groups and measures of physical function. Multivariable logistic regression evaluated risk factors for being in the OS group.Mean age of the OS patients was 80.4 ± 7.0 years. Our analyses showed that OS patients are older, mostly women, are at high risk for depression and malnutrition, have body mass index lower than 25, and showed a higher prevalence of peptic disease, inflammatory arthritis, maternal hip fracture, history of atraumatic fracture, and impaired mobility.We have reported a set of characteristics that are highly prevalent in OS patients. This study could be used to inform the design of future trials and to develop interventions to prevent institutionalization and poor outcomes in this particular set of high-risk patients. |
| Databáze: | OpenAIRE |
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