An Overview on the Field of Micro- and Nanotechnologies for Synthetic Peptide-Based Vaccines

Autor: José Luis Pedraz, Manoli Igartua, Rosa María Hernández, Aiala Salvador
Rok vydání: 2011
Předmět:
Zdroj: Journal of Drug Delivery
Addi. Archivo Digital para la Docencia y la Investigación
instname
Journal of Drug Delivery, Vol 2011 (2011)
ISSN: 2090-3022
2090-3014
DOI: 10.1155/2011/181646
Popis: 18 p. The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allow a better conservation, and are produced more easily and safely. However, they generate a weaker immune response than other vaccines, and the inclusion of adjuvants and/or the use of vaccine delivery systems is almost always needed. Among vaccine delivery systems, micro- and nanoparticulated ones are attractive, because their particulate nature can increase cross-presentation of the peptide. In addition, they can be passively or actively targeted to antigen presenting cells. Furthermore, particulate adjuvants are able to directly activate innate immune system in vivo. Here, we summarize micro- and nanoparticulated vaccine delivery systems used in the field of synthetic peptide-based vaccines as well as strategies to increase their immunogenicity. This project was partially supported by the “Ministerio de Ciencia e Innovación” (SAF2007-66115) and FEDER funds. A. Salvador thanks the “Universidad del País Vasco” for the Fellowship Grant.
Databáze: OpenAIRE