Mac-2: a versatile galactose-binding protein of mammalian tissues
| Autor: | Hughes Rc |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cell type
Glycosylation Galectin 3 Cellular differentiation Molecular Sequence Data Biochemistry Embryonic and Fetal Development chemistry.chemical_compound Lectins Animals Humans Amino Acid Sequence Receptor chemistry.chemical_classification biology Effector Macrophages Galactose Lectin Cell Differentiation Antigens Differentiation Neoplasm Proteins Cell biology Carbohydrate Sequence chemistry biology.protein Carbohydrate Metabolism Signal transduction Glycoprotein |
| Zdroj: | Glycobiology. 4:5-12 |
| ISSN: | 1460-2423 0959-6658 |
| DOI: | 10.1093/glycob/4.1.5 |
| Popis: | Mac-2 is a member of the S-(soluble) lectin family. Its identification and isolation from a wide variety of cell types and tissues suggest a diversity of roles in various biological systems. The key points to be made are that Mac-2, and the S-lectins in general, by virtue of their recognition of a variety of carbohydrate structures expressed on different glycoproteins, are well placed to exert discrete biological effects according to the distribution of those glycoproteins in tissues and their differential patterns of glycosylation according to developmental status and cell type. In this regard, the lectins are fundamentally different in character to other effector molecules that in general bind to specific receptors to trigger single signal transduction events. |
| Databáze: | OpenAIRE |
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