Decreased virulence of a strain ofPseudomonas aeruginosaO12 overexpressing a chromosomal type 1 β-lactamase could be due to reduced expression of cell-to-cell signaling dependent virulence factors

Autor: Françoise Ramisse, Eric Hernandez, Christian van Delden, Stéphane Gidenne, J.-D. Cavallo
Rok vydání: 2000
Předmět:
medicine.disease_cause
Rhamnose
Virulence factor
Mice
Rhamnose/analogs & derivatives/metabolism
chemistry.chemical_compound
Glucuronic Acid
Endopeptidases/metabolism
Immunology and Allergy
Pancreatic elastase
Pseudomonas Infections/microbiology
ddc:616
Mice
Inbred BALB C
Beta-Lactams
Pancreatic Elastase
Virulence
Hexuronic Acids
Drug Resistance
Microbial
General Medicine
Anti-Bacterial Agents
Pancreatic Elastase/metabolism
Infectious Diseases
Pseudomonas aeruginosa
Pseudomonadales
Female
Pseudomonadaceae
Microbiology (medical)
Alginates
Immunology
Biology
beta-Lactams
Microbiology
beta-Lactamases
Alginates/metabolism
Anti-Bacterial Agents/pharmacology
Endopeptidases
Decanoates/metabolism
medicine
Animals
Humans
Pseudomonas Infections
Decanoates
Rhamnolipid
Pneumonia
biology.organism_classification
Pneumonia/microbiology
chemistry
Pseudomonas aeruginosa/drug effects/genetics/ pathogenicity
Beta-Lactamases/genetics/ metabolism
Bacteria
Zdroj: FEMS Immunology and Medical Microbiology, Vol. 28, No 3 (2000) pp. 241-245
ISSN: 1574-695X
0928-8244
DOI: 10.1111/j.1574-695x.2000.tb01483.x
Popis: Pseudomonas aeruginosa produces a large variety of virulence factors and is characterized by its capacity to rapidly develop resistance when exposed to antibiotics. In order to evaluate a possible correlation between acquired resistance to antibiotics and virulence, we examined the virulence of four isogenic variants of P. aeruginosa O12 that differ in their resistance phenotypes to various beta-lactam antibiotics in a mouse model of acute pneumonia. Strains overproducing a chromosomal type 1 beta-lactamase were less virulent in both immunocompetent and immunosuppressed animals. Whereas the production of the exopolysaccharide alginate was similar between the four strains, extracellular virulence factors (elastase, rhamnolipid) that are controlled by the cell-to-cell signaling system circuit were detected in reduced amounts in the supernatant of the two isolates overproducing type 1 beta-lactamase. These results suggest that strains overexpressing the chromosomal type 1 beta-lactamase could be less virulent because of a reduction of cell-to-cell signaling dependent virulence factor production.
Databáze: OpenAIRE
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