Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation
| Autor: | Ketki Bhise, H. A. El-Banna, Samaresh Sau, M. Atef, Ghazal Nabil, Arun K. Iyer |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Biodistribution Polymers Future application Cancer imaging Gene delivery Article Patents as Topic 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Neoplasms Drug Discovery Tumor Microenvironment medicine Animals Humans Tissue Distribution Pharmacology Tumor microenvironment business.industry Cancer medicine.disease Clinical trial 030104 developmental biology Metals 030220 oncology & carcinogenesis Cancer research Nanoparticles Personalized medicine business |
| Zdroj: | Drug Discovery Today. 24:462-491 |
| ISSN: | 1359-6446 |
| Popis: | Cancer is the second highest cause of death worldwide. Several therapeutic approaches, such as conventional chemotherapy, antibodies and small molecule inhibitors and nanotherapeutics have been employed in battling cancer. Amongst them, nanotheranostics is an example of successful personalized medicine bearing dual role of early diagnosis and therapy to cancer patients. In this review, we have focused on various types of theranostic polymer and metal nanoparticles for their role in cancer therapy and imaging concerning their limitation, future application such as dendritic cell cancer vaccination, gene delivery, T-cell activation and immune modulation. Also, some of the recorded patent applications and clinical trials have been illustrated. The impact of the biological microenvironment on the biodistribution and accumulation of nanoparticles have been discussed. |
| Databáze: | OpenAIRE |
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