| Autor: |
Martin P. Snead, John D. Scott, Gregory S. Fincham, Annie McNinch, Allan J. Richards, Arabella V. Poulson, Laura Pasea, Christopher Carroll |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Ophthalmology. 121(8):1588-1597 |
| ISSN: |
0161-6420 |
| DOI: |
10.1016/j.ophtha.2014.02.022 |
| Popis: |
Purpose: The Stickler syndromes are the most common causes of inherited and childhood retinal detachment; however, no consensus exists regarding the effectiveness of prophylactic intervention. We evaluate the long-term safety and efficacy of the Cambridge prophylactic cryotherapy protocol, a standardized retinal prophylactic treatment developed to prevent retinal detachment arising from giant retinal tears in type 1 Stickler syndrome. Design: Retrospective comparative case series. Participants: Four hundred eighty seven patients with type 1 Stickler syndrome. Methods: Time to retinal detachment was compared between patients who received bilateral prophylaxis and untreated controls, with and without individual patient matching. Patients receiving unilateral prophylaxis (after fellow eye retinal detachment) were similarly compared with an appropriate control subgroup. Individual patient matching ensured equal age and follow-up between groups and that an appropriate control (who had not suffered a retinal detachment before the age at which their individually matched treatment patient underwent prophylactic treatment) was selected. Matching was blinded to outcome events. Individual patient matching protocols purposely weighted bias against the effectiveness of treatment. All treatment side effects are reported. Main Outcome Measures: Time to retinal detachment and side effects occurring after prophylactic treatment. Results: The bilateral control group (n ¼ 194) had a 7.4-fold increased risk of retinal detachment compared to the bilateral prophylaxis group (n ¼ 229) (hazard ratio [HR], 7.40; 95% confi dence interval [CI], 4.53e12.08; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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