Urinary excretion of glycosaminoglycans in patients with postmenopausal osteoporosis
| Autor: | S. Levi, G. Antov, A. Michailova, N. Topalova, Z. Toneva, St. Todorova |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Calcitonin medicine.medical_specialty Bone disease Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteoporosis Urine Biochemistry Bone remodeling Excretion chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Osteoporosis Postmenopausal Glycosaminoglycans Creatinine Estradiol business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Menopause chemistry Calcium Female business |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 24(12) |
| ISSN: | 0018-5043 |
| Popis: | The organic bone matrix contains glycosaminoglycans (GAG) of which the precise function and importance in bone mineralisation are still unclear. We examined 85 persons--35 healthy women (25 premenopausal [preMP] mean aged 40.7 years; 10 menopausal [MP] mean aged 59.3 years) and 50 patients with postmenopausal osteoporosis [PMOP] at a mean age 60.4 years. The dynamic of urinary excretion of GAG was measured in 24-hour collected urine by precipitation with cetylpyridinum chloride and spectrophotometry at 560 nm, corrected for the level of excretion of creatinine. There was a significant increase in GAG excretion in patients with PMOP compared with healthy persons (8.25 mg/g and 9.53 mg/g vs 24.11 mg/g; p < 0.0001). A significant positive correlation was established between GAG and calcium urinary excretion and a negative one between GAG and serum estradiol levels. During the treatment with calcitonin the excretion of GAG was decreased which can be used for monitoring the changes of bone metabolism. |
| Databáze: | OpenAIRE |
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