Genetic aspects of the effects of methylmercury in mice: The incidence of cleft palate and concentrations of adenosine 3′:5′ cyclic monophosphate in tongue and palatal shelf
| Autor: | Risa Burns, Kenneth Harper, Robert P. Erickson |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Embryology
medicine.medical_specialty Health Toxicology and Mutagenesis Biology Toxicology Mice chemistry.chemical_compound Species Specificity Tongue Inbred strain Pregnancy Internal medicine Cyclic AMP medicine Animals Allele Methylmercury Fetus Palate Incidence (epidemiology) H-2 Antigens Anatomy Methylmercury Compounds Adenosine Cleft Palate medicine.anatomical_structure Endocrinology chemistry Female Developmental Biology Biomedical sciences medicine.drug |
| Zdroj: | Teratology. 23:397-401 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420230315 |
| Popis: | Concentrations of adenosine 3':5' cyclic monophosphate (cAMP) were measured in the tongues and palates of 14.5-day-old fetuses from control and methylmercury-treated mothers of four inbred lines of mice which represent the four possible combinations of two H-2 alleles and two residual genetic backgrounds. The incidence of cleft palate in fetuses from control and methylmercury-treated mothers was also examined. The H-2 alleles significantly affected the degree of reduction of cAMP concentration in palates seen in fetuses from mothers treated with methylmercury. Neither the H-2 allele nor the residual genetic background played a role in the effect of methylmercury on cAMP concentrations in fetal tongues. The magnitude of increase in the incidence of cleft palate with methylmercury treatment was approximately the same for all lines. Thus, methylmercury-induced cleft palate may not be mediated by the reduction of cAMP. Finally, fetuses with cleft lip had increased palatal cAMP levels, whether or not they were from control or methylmercury treated mothers. |
| Databáze: | OpenAIRE |
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